custom infinium methylation array horvathmammalmethylchip40 (INFINIUM Inc)

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INFINIUM Inc custom infinium methylation array horvathmammalmethylchip40

( A ) Epigenome-wide association study of dpi in PBMCs based on the entire <t>methylation</t> array. The volcano plots display the −log 10 ( P values) and the directionality of association between CpG sites and infection stages (A, EC, and LC) compared with B: A versus B (left panel), EC versus B (center panel), and LC versus B (right panel). Each dot represents a specific DNAme site. Shown are significantly associated CpG sites ( q < 0.05) with hypomethylation (blue), hypermethylation (red), and nonsignificant (gray). The horizontal axis represents the mean methylation change (i.e., the difference between group means), and the vertical axis represents −log 10 ( P values). ( B ) Changes in EA during each infection stage (A, EC, and LC) relative to B. Biological age analysis was performed based on subsets of clock CpGs. EA at the 3 infection time points was compared with B using mixed-effects linear regression modeling of longitudinal EA changes in PBMCs based on 10 epigenetic clocks. The results are shown separately for young (right) and old (left) RMs. Epigenetic age changes in young (blue) and old (red) RMs are shown. Saturated colors indicate statistically significant changes ( P < 0.05); pale colors indicate nonsignificant changes ( P > 0.05). A statistically significant increase in EA was observed only in young RMs. B–H, Benjamini–Hochberg correction; DMP, differentially methylated positions; dpi, days after infection; RMs, rhesus macaques; B, baseline; A, acute; EC, early chronic; LC, late chronic; EA, epigenetic age.

Custom Infinium Methylation Array Horvathmammalmethylchip40, supplied by INFINIUM Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/infinium+methylation/custom+infinium+array+horvathmammalmethylchip40/pmc12259264-237-6-7
Average 90 stars, based on 1 article reviews

custom infinium methylation array horvathmammalmethylchip40 - by Bioz Stars, 2026-09

90/100 stars

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1) Product Images from "Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques"

Article Title: Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques

Journal: The Journal of Clinical Investigation

doi: 10.1172/JCI189574

( A ) Epigenome-wide association study of dpi in PBMCs based on the entire methylation array. The volcano plots display the −log 10 ( P values) and the directionality of association between CpG sites and infection stages (A, EC, and LC) compared with B: A versus B (left panel), EC versus B (center panel), and LC versus B (right panel). Each dot represents a specific DNAme site. Shown are significantly associated CpG sites ( q < 0.05) with hypomethylation (blue), hypermethylation (red), and nonsignificant (gray). The horizontal axis represents the mean methylation change (i.e., the difference between group means), and the vertical axis represents −log 10 ( P values). ( B ) Changes in EA during each infection stage (A, EC, and LC) relative to B. Biological age analysis was performed based on subsets of clock CpGs. EA at the 3 infection time points was compared with B using mixed-effects linear regression modeling of longitudinal EA changes in PBMCs based on 10 epigenetic clocks. The results are shown separately for young (right) and old (left) RMs. Epigenetic age changes in young (blue) and old (red) RMs are shown. Saturated colors indicate statistically significant changes ( P < 0.05); pale colors indicate nonsignificant changes ( P > 0.05). A statistically significant increase in EA was observed only in young RMs. B–H, Benjamini–Hochberg correction; DMP, differentially methylated positions; dpi, days after infection; RMs, rhesus macaques; B, baseline; A, acute; EC, early chronic; LC, late chronic; EA, epigenetic age.

Figure Legend Snippet: ( A ) Epigenome-wide association study of dpi in PBMCs based on the entire methylation array. The volcano plots display the −log 10 ( P values) and the directionality of association between CpG sites and infection stages (A, EC, and LC) compared with B: A versus B (left panel), EC versus B (center panel), and LC versus B (right panel). Each dot represents a specific DNAme site. Shown are significantly associated CpG sites ( q < 0.05) with hypomethylation (blue), hypermethylation (red), and nonsignificant (gray). The horizontal axis represents the mean methylation change (i.e., the difference between group means), and the vertical axis represents −log 10 ( P values). ( B ) Changes in EA during each infection stage (A, EC, and LC) relative to B. Biological age analysis was performed based on subsets of clock CpGs. EA at the 3 infection time points was compared with B using mixed-effects linear regression modeling of longitudinal EA changes in PBMCs based on 10 epigenetic clocks. The results are shown separately for young (right) and old (left) RMs. Epigenetic age changes in young (blue) and old (red) RMs are shown. Saturated colors indicate statistically significant changes ( P < 0.05); pale colors indicate nonsignificant changes ( P > 0.05). A statistically significant increase in EA was observed only in young RMs. B–H, Benjamini–Hochberg correction; DMP, differentially methylated positions; dpi, days after infection; RMs, rhesus macaques; B, baseline; A, acute; EC, early chronic; LC, late chronic; EA, epigenetic age.

Techniques Used: Methylation, Infection

Activation Assay:

Article Title: Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer
Article Snippet: .. Renal carcinoma shows lower frequency of both transcriptional activation of CT-RERG and hypermethylation of PTPRO and RERG downstream promoters. (A) The frequency of activation of CT-RERG transcription (TPM>1) was evaluated in liver hepatocarcinoma (LIHC, n=369) and renal papillary cell carcinoma (KIRP, n=273) through the analysis of RNA-seq data from the TCGA. (B) The frequency of hypermethylation of PTPRO and RERG promoters in these same tumor samples were evaluated through the analysis of Infinium methylation data from the TCGA (probe intensity ratio > 0.2, as explained in Fig.6H-I). ..

RNA Sequencing:

Methylation:

Article Title: A global profile of gene promoter methylation in treatment-naïve urothelial cancer
Article Snippet: .. The Infinium methylation value for representative genes was verified by pyrosequencing. ..

Article Title: Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
Article Snippet: .. Conversely, AluYb8 (median 85%, IQR 3.0%) and mean Infinium methylation (median 27%, IQR 3.3%) values were much more tightly distributed. fig ft0 fig mode=article f1 caption a4 Summary HNSCCs. ..

Article Title: DNA methylation plasticity of human adipose-derived stem cells in lineage commitment.
Article Snippet: .. A: Two-dimensional scatterplots of Infinium methylation ntiated cell sample for each lineage. ..

Article Title: A systematic assessment of normalization approaches for the Infinium 450K methylation platform
Article Snippet: .. 9 - 11 Briefly, the Infinium methylation technology is built upon the same technology as is used for genotyping SNPs. ..

Article Title: Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer
Article Snippet: .. In addition, there were clear relationships between LUMA and LINE-1 methylation as well as between LUMA and Infinium methylation, suggestive of a link between global- and gene-targeted methylation. ..

Article Title: Current understanding of epigenetics role in melanoma treatment and resistance
Article Snippet: .. Infinium methylation technology identified some CpG sites, associated with more than 14,495 cancer-related genes with significant methylation differences (44 hypomethylated and 106 hyper-methylated CpG islands) [ ]. ..

Article Title: A genome-wide DNA methylation study in colorectal carcinoma.
Article Snippet: Illumina’s methylation assay has been compared to other platforms by others and has shown dependable results with the correlation ranging from 0.8 to 0.9 [32,33,38]. .. We also have validated the methylation data form Infinium methylation for 12 of the highly differentially methylated genes in our study and also found similar high correlations with Methyl Profiler assay (see Additional File 1 Table-S4 and Additional File 5 Figure S4). .. In another study, reproducibility tests of Infinium methylation platform was reported to have correlation greater than 0.98 between technical replicates [39].

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